Recruitment

People may learn about the PACT study through community events, postcards, emails, flyers, or local ads.

Initial Phone Screening

A study team member calls interested individuals for a short phone screening which includes:

  • Basic questions about you and your health
  • A brief memory check

If basic criteria are met, the first study visit is scheduled at a nearby site.

Visit 1: Getting Started

At the first visit, study staff:

  • Review the consent form and answer questions
  • Check memory, thinking, and mood
  • Ask participants to complete short questionnaires

Once enrolled, participants:

  • Begin their first computerized brain training session
  • Are asked to try one training session at home
  • Provide a blood sample, if they choose

Visit 2: Learning the Training Program

At Visit 2, participants:

  • Complete a training session
  • Make a plan to complete the remaining initial at-home training sessions

At-Home Training and Booster Sessions

After enrollment, participants complete training at home using a computer or tablet.

  • First stage: 25 initials at-home training sessions
  • About 1 year later: 10 booster training sessions
  • About 18 months after that: 10 more booster training sessions

In total, participants complete 45 at-home sessions spread over several years.

PACT staff will periodically contact participants to check-in on them and their progress across this time period.

3-Year Follow-Up Visit(s)

Around the third year of enrollment, participants are invited back to their closest study site.

During this visit, we:

  • Repeat memory, thinking, and mood checks
  • May complete more comprehensive assessments
  • Offer the option to provide a blood sample

Following this visit, we may ask participants to complete an evaluation with a study physician as well as an MRI scan to learn more about their brain health.

Possible Follow-Up Beyond Year 3

The trial may be extended for further follow-up after the 3-year visit.

If the study continues, we will contact interested participants with details, as participation will be optional.